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Erratum in: J Am Coll Cardiol 2012;59(24):2306 Eagle KA, Berger PB, Calkins H, Chaitman BR, Ewy GA, Fleischmann KE, et al

How often do these birth effects occur

However, it should also be recognized that it may be difficult to definitively demonstrate whether DPP-4 does play a physiologically relevant role in cleaving some endogenous substrates in vivo because it can be difficult to distinguish between the intact substrate and the truncated metabolite (because assays are not specific or sensitive enough) and/or because it may be difficult to obtain appropriate samples (e.g., from synapses [neurotransmitters] or interstitial fluid [paracrine signallers])

The first actual incretin was described in 1973: glucose-dependent insulinotropic polypeptide, also known as gastric inhibitory polypeptide (GIP)