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These findings provide objective evidence supporting the previously discussed clinical manifestations and underlying neurotoxic mechanisms
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By moderating eumelanin (dark pigment) and favouring pheomelanin (lighter pigment), it may contribute to a more even skin tone over time
thus, the final dose for each arm (5, 10, and 15 mg) was respectively achieved after four, twelve, and twenty weeks from randomization with a considerable difference in time of exposure to TZP 5 mg (36 weeks), TZP 10 mg (28 weeks), TZP 15 mg (20 weeks)
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