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According to the World Health Organization (WHO), there were approximately 1.9 billion overweight adults in 2016, of which 650 million were obese (2, 3)
In clinical trials, semaglutide (Wegovy) averaged about 14.9% of body weight over 68 weeks in the STEP 1 trial, and tirzepatide (Zepbound) averaged about 20.9% at the highest studied dose in SURMOUNT-1
Data availability The data of molecular traits used to proxy GLP-1R expression were available via deCODE genetics website ( the eQTL Gen website ( the GoDMC website ( the MetaBrain website ( and the Genotype-Tissue Expression (GTEx) Portal website ( The summary statistics of ovarian cancer for GWAS meta-analyses used in this study are deposited in the IEU OpenGWAS database (GWAS IDs ieu-a-1120 and ieu-b-4963) and FinnGen r12 defined as II Neoplasms, from cancer register (ICD-O-3) ( The GWAS summary statistics for the ovarian cancer subtypes are available at with their GWAS IDs listed in the Supplementary Data
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