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Treatment protocols for KLOW are determined by the prescribing clinician based on an individual patients health history, goals, and clinical assessment
All these potentially impact the production of pineal melatonin, an important temporal cue of biological rhythms
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Despite some positive effects of GSH pretreatment on resistance of old myocardium to I/R, the improvement of heart function recovery was not observed in the late period of reperfusion that may indicate exhausted intrinsic antioxidant reserves of the myocardium, so further studies are needed for the investigation of long-term increase of myocardial resistance to I/R
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