Recent data indicate that women with CSU present with more comorbidities than men, including asthma, thyroid disease, obesity, autoimmune conditions, gastrointestinal disorders, and depression [10]
Gorboulev, V
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To overcome these challenges, as well as to improve the permeation of proteins and peptides via intestinal mucosa, several chemicals have been studied such as surfactants, fatty acids, bile salts, pH modifiers, and chelating agents, amongst these medium chain fatty acid like C10 (sodium caprate) and Sodium N-[8-(2-hydroxybenzoyl) amino] caprylate (SNAC) and its derivatives that have been well studied from a clinical perspective