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The FDA evaluates safety, efficacy, and quality through the New Drug Application (NDA) process before approval and requires ongoing post-market safety monitoring
Its extended 2030 hour half-life means once-daily subcutaneous injections maintain stable elevated serum IGF-1 throughout the 24-hour cycle
In the intention-to-treat analysis, compared with GLP-1 receptor agonists, the risk of kidney failure was significantly lower with SGLT2 inhibitors (hazard ratio [HR], 0.82
doi: 10.1186/s12929-020-00703-5 283 TuW.WangH.LiS.LiuQ.ShaH
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