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Tirzepatide activates both the GLP-1 and GIP (glucose-dependent insulinotropic polypeptide) receptors, whereas semaglutide targets only GLP-1
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When the FDA declared a national shortage of semaglutide, a GLP-1 receptor agonist, in March 2022, compounding pharmacies gained legal permission to produce custom versions of Novo Nordisks key ingredient in Ozempic and Wegovy
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