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namely, reduced affinity of TPO for H 2 O 2 was associated with the formation of severe multinodular goiter in mice [147]
Reprogrammed cells expressed key transcription factors of -cell identity (Pdx1, MafA, FoxA2), while the morphology and function of the rat intestinal epithelium remained intact (Duan et al., 2015)
Interestingly, with progressive increase in IOP, autophagy is initially activated in the dendrites of RGCs and protects cells, but its subsequent activation in the cytoplasm disrupts homeostasis and induces cell death 21,22,70,71,72
The core philosophy is to "close the window first," mitigating these primary causes before addressing the subsequent aging markers
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