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Despite their effectiveness, concerns remain regarding safety, tolerability and potential health risks, as well as the need for long-term administration and the subsequent cost

According to the STEP 1 trial published in the New England Journal of Medicine, patients taking semaglutide 2.4 mg (Wegovy) achieved approximately: 3% to 5% body weight loss by week 12 10% to 12% body weight loss by week 28 15% to 17% body weight loss by week 68 (maximum effect) These figures represent average outcomes in clinical trials

It contains tirzepatide, which acts on both GLP-1 and GIP receptors

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