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a phase I/II trial in 36 patients with heavily-pretreated mCRPC demonstrated a 14.3% objective response rate, a 95.2% disease control rate, and improvements in PSA levels, as well as a manageable safety profile with cytopenias as the most common grade 3 TRAE (CTR20231298) 101
for 2 days at a loading dose of 70 mg/kg per day (Israel et al., Figures 3, 7, 8), we used a shorter treatment period (2 or 4 days) and a higher concentration of NAC (100 mg/kg per daily) and ASA (15 mg/kg per day, Figure 7
If you forget to take your tablet, the best approach is to skip the missed day entirely and resume your usual schedule the following morning
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