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Only one of the trials included in the systematic review used the next-generation GLP-1 agonist semaglutide to treat obesity in adolescents aged 1218 years, and none used the combined GLP-1 and glucose-dependent insulinotropic peptide agonist, tirzepatide
It is highly beneficial for patients with peripheral heart disease
Moreover, liraglutide trials in patients with HFrEF provided no clinical benefit, underscoring that the efficacy of incretin receptor agonism does not uniformly extend across heart-failure phenotypes and that remodelling mechanisms may differ by disease context [47]
anaphylaxis to injectable thiamine, while extremely uncommon, has been reported
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