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In the low-overdose patient (A), the maximum number of necrosed cells was 46 of 5,114 cells (0.89%) without zonation, which increased to 79 necrosed cells when applying 80% zonation (see Figure 4)

Long-term use may reduce vitamin B12 absorption, and the MHRA advises considering periodic monitoring in at-risk patients and testing if symptoms of deficiency develop

A recent systematic review and meta-analysis observed that adults with obesity or overweight who were administered GLP-1 analogs for at least 12 weeks, showed a significant overall improvement in excess weight loss when compared to a placebo, with a weighted mean difference of 3.11 kg [28]

This GLP-1 receptor agonist mimics natural hormones in the body that regulate hunger and digestion