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It belongs to a novel class of agents sometimes referred to as 'triple agonists' because it simultaneously activates three hormone receptors: the glucagon-like peptide-1 (GLP-1) receptor, the glucose-dependent insulinotropic polypeptide (GIP) receptor, and the glucagon receptor
Crugnola V, Lamperti C, et al
Interestingly, both Nrf2 and HO1 co-localized with reactive astrocytes, the major GSH suppliers for neighboring neurons, in the degenerating spinal cord of SOD1 G93A rats, and this was interpreted as a reactive attempt to prevent cell death
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