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The leached amount would be attributed to the poor association/adsorption of a small fraction of the AuNCs with/at the surface of PLGA in resemblance to the known burst release of encapsulated drugs in PLGA nanohosts
Key points to consider when interpreting the evidence: Most studies are short-term , typically lasting fewer than 12 weeks, making it difficult to assess long-term efficacy or safety Results appear more pronounced in older adults or individuals with obesity, compared to younger, healthy populations L-carnitine alone, without dietary or lifestyle changes , is unlikely to produce clinically meaningful weight loss Neither NICE nor the NHS recommends L-carnitine supplementation as part of any weight management pathway
Am J kidney Dis Off J Natl Kidney Found 46:143146 Hylemon PB, Zhou H, Pandak WM, Ren S, Gil G, Dent P (2009) Bile acids as regulatory molecules
[PubMed ID: 655387]
