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140 Whereas the continuous supply of FeS clusters by NFS1 also prevented the iron-starvation response from being triggered in lung adenocarcinomas, NFS1 suppression was shown to predispose cancer cells to ferroptosis

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Nrf2 activation suppresses ROS in antigen-presenting dendritic cells enhancing their capacity to interact with and promote the transformation of nave CD8 T cells into cytotoxic T lymphocytes enabling cytotoxic T-cells to eliminate virally infected cells (Kesarwani et al., 2013