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The EXSCEL trial (Bethel et al., 2020) and LEADER trial (Marso et al., 2016) investigated the effect of exenatide and liraglutide, respectively, on microvascular and cardiovascular outcomes in patients with type 2 diabetes
Thus, sustained PERK pathway activation integrates proteostasis control with angiogenic and invasive programs, positioning this UPR branch as a central driver of tumor progression rather than a mere stress-response mechanism
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