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This review highlights the biological activities of IGF-IR signaling in cancer and the contribution of IGF-IR to cytotoxic, endocrine, and molecular targeted therapies resistance
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Competing Interest The authors declare no competing financial interests or personal relationships that could have influenced the work reported in this paper
Current research developments focus on expanding FOXO4-DRI applications beyond traditional aging studies to include investigation of fibrosis, neurodegeneration, and immune system aging
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