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DSIP has been investigated for its role in sleep regulation, neuroendocrine modulation, and stress response across numerous preclinical studies over more than four decades

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As the WL achieved with the novel obesity pharmacotherapies approaches that of bariatric surgery, we will need to assess whether long-term complications observed after bariatric surgery such as increased risk of osteoporosis, fractures, macro- and micronutrient deficiencies as well as self-harm behaviours will also be present with pharmacotherapy [112, 113]