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[53] In two of these (NCT03954834 and NCT04039503), participants were randomly assigned to receive either tirzepatide or placebo injection weekly
Once-weekly preparations such as dulaglutide and extended-release exenatide produce more stable plasma concentrations with fewer peak-to-trough fluctuations compared with daily or twice-daily formulations
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They ran four parallel studies based on different patient profiles: ADM trial: Patients with type 2 diabetes (T2D), comparing newer GLP-1 RAs to older GLP-1 RAs, sulfonylureas, and other anti-diabetic medications (ADMs)
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