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JAMA 334 , 12311234 (2025)

A 2025 retrospective cohort study of 210 T2DM patients on oral semaglutide for 18 months found no significant association between rs6923761 or rs761387 genotypes and changes in HbA1c or BMI in that relatively well-controlled population (Candido et al., 2025) suggesting that receptor-level genotype effects may be detectable primarily in subpopulations with higher pharmacological demand or larger baseline disease severity, rather than as universal predictors

Thats why we recommend B12 injections only when there is a medically diagnosed deficiency or an absorption issue that prevents you from getting enough B12 through your diet

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