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In both comparisons, the semaglutide group demonstrated a significantly greater weight loss, and semaglutide led to more than double the weight reduction compared to dulaglutide at matched doses
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Exendin-4 is not the GLP-1 of the Gila Monster [it has its own GLP-1 with a much higher homology, in agreement with the finding that the sequence is highly conserved among species with 100% identity among all mammals so far investigated (108)], but is nevertheless a full and potent agonist of the mammalian GLP-1 receptor
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