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Since SCFAs are also signalling molecules and ligands of two different transmembrane G protein-coupled receptors, FFAR2 and FFAR3 30,31 , the impact of FXR activation on GLP-1 secretion in response to synthetic ligands of FFAR2 and FFAR3 was assessed
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125 Bacterial or viral infection is a common trigger for COPD exacerbations, and exposure to LPS induces p38MAPK activation in rat peritoneal macrophages and dendritic cells as well as an increase expression of inflammatory mediators
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