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doi: 10.1038/sj.bjc.6602619 11 LarssonSCOrsiniNBrismarKWolkA
Our findings describe a role for mitochondrial plasticity as a mechanism for acute 5FU tolerance in CRC cells: mitochondrial changes acutely adopted by CRC cells in response to 5FU-based standard-of-care treatment result in increased mitochondrial biogenesis, which provides metabolic support for increased pyrimidine scavenging by UCK2 to resolve nucleotide stress
The severity and duration of these side effects can often be influenced by the dosage of the medication
Managing bloating can include eating smaller, more frequent meals, avoiding high-fat and high-fiber foods, staying hydrated, and engaging in regular physical activity
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