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Ligand binding drives receptor autophosphorylation, IRS-1/IRS-2 adapter recruitment, and activation of two primary downstream cascades: PI3K/Akt/mTOR (governing protein synthesis, glucose uptake, and cell survival) and MAPK/ERK (regulating cell proliferation and differentiation)

While CEA alone is not sufficient for diagnosis, it improves prognostic stratification when used alongside CA19-9 and CA125, especially in predicting chemotherapy resistance and surgical outcomes [77, 78]

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Alexander GolBerg MD, DO is a board-certified physician with over 25 years of clinical experience in functional and regenerative medicine in New York City