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The published literature on this combination draws on the extensive individual evidence bases for both components, with the dual-pathway synergy mechanistically supported by peer-reviewed porcine and in vitro data
242 Astragaloside IV inhibits the PI3K/Akt/mTOR pathway by upregulating miR-155 expression, thereby preventing apoptosis and enhancing autophagy to alleviate myelin damage in Schwann cells and improve neurological function in DPN rat models
The probiotic Lactobacillus casei Zhang-mediated correction of gut dysbiosis ameliorates peritoneal fibrosis by suppressing macrophage-related inflammation via the butyrate/PPAR-/NF-B pathway
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