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FDA lists BPC-157 on its compounding-safety page among withdrawn bulk-substance nominations
For example, while many people with Alzheimers disease are found to have low vitamin B12 levels, there is no improvement in cognitive function after supplementation with high doses of vitamin B12
Well-structured treatments lasting 6-12 months with appropriate concentrations typically maintain noticeable improvements over pre-treatment baseline including reduced fine lines (though not eliminated as during peak treatment), improved skin texture and firmness (though less dramatic than treatment peak), better overall skin quality and appearance (though aging continues at normal rates), and resolved specific issues like scarring or hyperpigmentation (which typically remain improved permanently if successfully treated)
The other two routes, 4-hydroxyestrone (4-OHE1) and 16-hydroxyestrone (16-OHE1), produce metabolites that remain more estrogenically active and continue to stimulate estrogen-sensitive tissue [1, 2]
