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GLP-1 gastrointestinal effects in women Nausea, reduced appetite, constipation and other digestive symptoms are common, particularly when starting GLP-1 medications or increasing doses
Whether or not people can successfully de-escalate could be related in part to how they metabolize the drug and the length of that steady state, Pinto says
in rodents it is described as unusually resistant to degradation Sikiric et al., 2025
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