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Lower levels of malonyl-CoA disinhibit carnitine acyltransferase 1, allowing fatty acid import to the mitochondria, ultimately replenishing the supply of ATP
FOXO4-DRI enhances tissue rejuvenation By clearing out senescent cells, FOXO4-DRI can cause a significant increase in the regeneration of tissues and may restore their functionality, making it a promising agent for reversing cellular aging effects (4)
However, this observation is somewhat difficult to reconcile with modelled data (Polle 2001)
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