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Chemical derivatisation of metabolites All freeze-dried samples were derivatised using the MCF method described by Smart et al

That is much better than the NNT for established treatments, which come in at 7 or higher

The GLP-1 RAs appear to modify atherosclerosis in the arteries, much like statin medications that treat cholesterol, and takes about a year or more to demonstrate measurable benefits on risk for cardiovascular events, whereas the SGLT2i medications seem to affect heart and kidney function more prominently and faster, with benefits evident very soon after starting the medication

In September 2023, the U.S