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These changes can affect identity, self-image, and relationships, especially for individuals with a history of shame, stigma, or disordered eating

This molecule, as well as the broader pipeline, placed Metsera at the centre of a fierce bidding war between Pfizer and Novo Nordisk in late 2025, with an eventual deal value of around ~US$10bn

This perverse outcome where a more expensive branded drug maintains formulary position over cheaper biosimilars through rebate structures has drawn significant criticism from patient advocates, biosimilar manufacturers, and academic health economists

Furthermore, the administration of denatonium benzoate, in conjunction with gavage of glucose, causes the secretion of GLP-1 and subsequently elevates plasma insulin levels and reduces plasma glucose in db/db mice [195]