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The proportion of the epithelioid cells varied from patient to patient, with a mean of 51% (range: 20% to 95%) ( Table 3 )

RA was diagnosed based on the American College of Rheumatology (ACR) guidelines and the severity of rheumatoid arthritis (RA) was assessed according to the Disease Activity Score 28 (DAS 28)

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Although brain infarction volume reduction did not reach statistical significance, motor performance in the rotarod test significantly recovered in DSIP-treated animals compared to vehicle controls confirming a functionally relevant neuroprotective effect at the behavioural level and establishing intranasal delivery as a viable route for CNS DSIP research