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In rodents, semaglutide activates GLP-1 receptors in the thyroid, which stimulates calcitonin release, upregulates expression of the calcitonin gene, and causes hyperplasia of C-cells
However, when intracellular glutathione is well below this homeostatic level, GCL is no longer inhibited and can actively utilize the cysteine that NAC supplies
Mitochondrial biogenesis does happen, but you have to stimulate it to happen
The recent approval came after two medical trials found that Tirzepatide demonstrated significant weight loss compared to control groups who received a placebo
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