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A novel enzyme (the bifunctional glutathione synthetase encoded by gshF ) that possessed both -GCS and GS activities and was non-sensitive to GSH was discovered in several microorganisms, including Streptococcus agalactiae [10], Enterococcus faecalis [10], Listeria monocytogenes [11], and Streptococcus thermophiles [12]

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It was developed as an alternative medication (or adjuvant medication) for insulin, insulin secretagogues, and drugs like metformin

If similar effects occur in humans, adding niacinamide to a tirzepatide regimen could theoretically amplify fat loss and improve metabolic flexibility