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No serious adverse events were attributed to leucovorin in these studies [8]
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Philp, D., Badamchian, M., Scheremeta, B., et al
However, liver mitochondria from mice lacking ANT1 and ANT2 can still undergo Ca 2 + -induced swelling and MPT, although at a higher threshold, which has been interpreted as evidence against a role for ANT in MPT (Kokoszka et al., 2004)
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