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4-7 During midlife, the decreased amount of estrogen in a womans musculoskeletal system results in loss of lean muscle mass, loss of bone density, increased risk of fracture, increased injury to tendons and ligaments, adhesive capsulitis, cartilage matrix fragility leading to osteoarthritis, musculoskeletal pain, and metabolic dysfunction
PMID 18272931.
Some clinics use a shorter interval of around seven to ten days for small areas, while others prefer four to six weeks so any swelling fully resolves first
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