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If you notice persistent redness, itching, or stinging, stop and reconsider
Some clinicians use oral as a maintenance route after an initial subcutaneous course, but this is pragmatic, not evidence-defined
Users should introduce retinoids gradually 2-3 times weekly, applying well away from lash line, and monitoring carefully for dryness or irritation requiring protocol adjustment
doi:10.1016/j.ajpc.2024.100679
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