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4 Studies in animals have led to concerns about the risk of acute pancreatitis and medullary thyroid carcinoma (MTC)

Sources disagree

A 2026 study using alanine substitution of phosphorylation sites with single-residue resolution demonstrated that the distal C-tail site primarily governs -arrestin recruitment dwell time, while proximal sites control internalization rate and cAMP duration (Tran et al., 2026)