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No large-scale phase 3 trials have been completed
2017 meta-analysis: A meta-analysis of 17 clinical trials including 1,625 adults with chronic heart failure found that 16 g/day L-carnitine supplements for 7 days to 3 years improved left ventricular ejection fraction by 4.14%, stroke volume by 8.21 mL, and cardiac output by 0.88 L/min compared to routine treatment
It is hypothesized that Lycopene may have additional positive effects on the testis through non-oxidative mechanisms like gap junction communication, gene expression regulation, cell cycle control, and immune enhancement
Without formal studies on this phenomenon, anecdotal accounts describe what appears to be accelerated skin aging rather than antiaging benefits
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