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Experimental investigations commonly focus on its interaction with glutathione peroxidases, glutathione S-transferases, and redox-sensitive signalling proteins

Acetoacetate can undergo spontaneous decarboxylation to acetone, or be enzymatically converted to -hydroxybutyrate (BHB) through the action of mitochondrial -hydroxybutyrate dehydrogenase which is encoded by the BDH1 gene

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