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They include: regular physical activity eating a healthy balanced diet getting an adequate amount of quality sleep maintaining a healthy weight avoiding tobacco and alcohol controlling blood pressure and cholesterol numbers Experts say a heart-healthy diet should avoid ultra-processed foods, sugars, and unhealthy fats

"So instead of one simple target, targeting two or three different receptors can lead to either additive or synergistic weight loss and diabetes control." It's not yet clear all the levels at which these weight-loss drugs work, but appetite and satiety are definitely two, Jastreboff and Saunders said

Human trials have predominantly used topical or brief systemic dosing, and tolerability is overall reported to be good

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