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Appears to enhance weightloss and glucose effects when combined with GLP1, based on dualagonist data (such as tirzepatide). Glucagon receptor activation Increases energy expenditure and promotes fat oxidation when balanced properly with GLP1 and GIP. May help reduce liver fat and visceral (deep abdominal) fat, which are strongly linked to cardiometabolic risk. By combining these three pathways, retatrutide aims to reduce appetite, improve metabolic control, and increase calorie burning more strongly than current single or dualagonist drugs

Compounded tirzepatide is not reviewed by the FDA for safety, effectiveness, or quality

But this is usually an effect that is quickly felt

Plant-Based Foods Soy (tofu, tempeh, edamame) : Contains lunasin, a peptide with anti-inflammatory benefits