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Nausea is the most common side effect, often experienced when starting the medication or increasing the dose

Medical professionals also recommend that men take folic acid when trying to conceive, as it can improve the quality of their sperm

Breaks make sense for users experiencing treatment plateau where benefits cease increasing despite continued application suggesting diminishing returns from ongoing use, comfortable with some benefit decline during off periods accepting fluctuation in skin quality, budget-conscious seeking to minimize annual treatment costs through intermittent purchasing, philosophically preferring avoiding indefinite dependency on any skincare product, planning life changes incompatible with consistent application (extended travel, relocation, financial shifts), and wanting to assess whether improvements prove durable or require continuous maintenance before committing to indefinite treatment

Incorporating omega-3 rich foods or high-quality supplements early in recovery may offer supportive benefits, particularly for athletes and students seeking a quicker return to academic and physical activity