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On the same day of infection, PBMCs were either sham treated (untreated) or treated with 1/10 the minimum inhibitory concentration 1/10 MIC of PZA (5 micrograms/ml), and (MIC) of INH (0.125 micrograms/ml)
This clinical improvement correlated with upregulation of anti-inflammatory IL-10 and concurrent downregulation of the pro-inflammatory cytokines TNF- and IL-1 (251)
Nucleotide-binding oligomerization domain (Nod)-like receptor (NLR) signaling via pattern recognition receptors also depends on PPP flux, which can affect intracellular sensing by macrophages of pathogens, such as Aspergillus (17)
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