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For example, mucus secretion is mediated by the induction of the MUC5AC gene in goblet cells through several independent pathways, including the CLCA1 (a Serpin)- and 15-lipoxygenase-1-dependent pathways

10.1046/j.1471-4159.2001.00383.x J

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In recent years, we added an epigenetic component to the Allostasis/Allostatic load model to describe how non-shared environmental experiences may set each individual on a somewhat different trajectory of development that determines either adaptive or maladaptive responses (behavior, systemic function and vulnerability to disease) to subsequent novel experiences as the life course unfolds [20]