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From early acid-driven magnesium-based micromotors for gastric ulcer treatment, which utilize gastric acid to generate hydrogen bubbles for propulsion and local drug release [43], to the emergence of multifunctional MNMs today (e.g., bacteria-driven microrobots targeting gut microbiota for IBD therapy [44]), these advancements highlight the potential of MNMs to improve drug bioavailability, reduce systemic toxicity, and enhance patient compliance, holding promise to revolutionize the treatment of digestive system diseases

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De Vecchi, A