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[3] Carnitine acyltransferase I undergoes allosteric inhibition as a result of malonyl-CoA, an intermediate in fatty acid biosynthesis, in order to prevent futile cycling between beta-oxidation and fatty acid synthesis
then titrate or switch if needed
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IRS-1 activates phosphatidylinositol 3-kinase by associating with src homology 2 domains of p85
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