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Over the same time, 66% of the tirzepatide group lost 10% or more of their initial weight, while only 41.1% of the semaglutide group reached that threshold

5,55 During the first phase of insulin secretion, islet beta-cells readily secrete synthesised insulin stored in vesicles during the initial minutes after these cells sense blood glucose concentrations of 5mM

In a 2021 study published in the New England Journal of Medicine, participants treated with semaglutide lost an average of about 15 percent of their body weight, compared with a loss of 2.4 percent in the placebo group