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Nrf2 was found to participate in transcriptional activation of antioxidant enzymes that act as a cell defensive system to detoxify NAPQI (Goldring et al., 2004)
Under hypoxic or hyperglycemic conditions, the accumulation of HIF1 markedly drives renal tubular cell ferroptosischaracterized by HO1/TFRC upregulation, iron overload, and lipid peroxidation
Its levels also decline with age
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