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doi: 10.1016/j.ando.2022.12.423
However, whilst intravenous infusion of GLP-1 was effective (16), the insulinotropic effect of a single subcutaneous injection was surprisingly short-lived, with insulin levels peaking at 30 min before returning toward baseline within 90 min, even though glucose levels were still well within the hyperglyacemic range and circulating immunoreactive GLP-1 levels were significantly elevated for several hours (17)
Semaglutide works by mimicking the action of glucagon-like peptide 1 (GLP-1), a naturally occurring hormone that has the following effects: Stimulates insulin production to help regulate blood sugar Inhibits glucagon release, slowing the release of sugar into the blood, causing the body to burn more fat Slows gastric emptying to make you feel full longer Reduces appetite (because you feel full) Together, these effects can help you slow the conversion of sugar to fat, burn more fat, feel less hungry, and adhere to a healthy diet, all of which make managing weight and blood sugar easier
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