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These current drugs are big molecules (peptides) and for this reason must be injected as theyre not absorbed effectively in the gut

Mounjaro is also approved for the treatment of type 2 diabetes

The X-box-binding protein-1 (XBP1), spliced and activated by IRE1, is downregulated in glomerular mesangial cells, weakening the inhibitory effect on the phosphatase and tensin homolog (PTEN)/Akt pathway, thereby aggravating kidney damage